Having published over 200 papers and been invited to speak at over 300 conferences, Professor Bouvier is an international expert in molecular pharmacology. He is a professor of biochemistry and molecular medicine and principal investigator at the Institute for Research in Immunology and Cancer (IRIC). His work is focused on G protein-coupled receptors (GPCRs)—a family of proteins that play a key role in controlling a range of biological processes and represent a major therapeutic target—and brought about a paradigm shift in our understanding of drug action and the development of methods for new therapies. In concrete terms, his lab set out bioluminescence resonance energy transfer (BRET) techniques to study protein-protein interactions in living cells in real time to elucidate signalling complexes. These new approaches make it possible to select and create new therapeutic molecules by taking advantage of large data sets that describe their mechanisms of action. His team includes professional research assistants, postdoctoral research fellows, master’s and PhD students and research agents. The research program has led to several partnerships with pharmaceutical industry stakeholders to develop innovative therapies. For many years, Professor Bouvier led IRICoR, a not-for-profit organization that he helped found and which aims to translate drug discovery projects by IRIC researchers and their collaborators into marketable innovations.
Professor Bouvier holds a bachelor’s in biochemistry and a PhD in neurological sciences from Université de Montréal. He carried out his postdoctoral training at Duke University with Dr. Robert J. Lefkowitz (2012 Nobel Prize in Chemistry). He is a principal investigator and the chief executive officer of the IRIC and holds the Canada Research Chair in Signal Transduction and Molecular Pharmacology. He also serves as the deputy vice-rector of research, discovery, creation and innovation at Université de Montréal. He regularly chairs and sits on peer review committees and scientific councils for pharmaceutical and biotechnology firms and government agencies.
Awards and honours
In his career, Professor Bouvier has received a number of awards and honours. In March 2012, he received the Senior Investigator Award from the Canadian Society for Molecular Biosciences in recognition of his exceptional contribution to the field. In 2014, he ranked among the world’s most cited scientists in all disciplines according to Thomson Reuters indicators. Professor Bouvier was also elected Fellow of the Academy of Sciences of the Royal Society of Canada.